An extensive article dealing with local ancestry, defined as the genetic ancestry at a genomic location of an admixed individual, has been posted as a Scientific Report at the website of Nature. Honestly, I was lost before I hardly got started reading the math-heavy report. However, I figure there are a few of my readers that just might understand. So I am posting the initial Abstract, and a link to the page.
ABSTRACT
Local ancestry, defined as the genetic ancestry at a genomic location of an admixed individual, is widely used as a genetic marker in genetic association and evolutionary genetics studies. Many methods have been developed to infer the local ancestries in a set of unrelated individuals, a few of them have been extended to small nuclear families, but none can be applied to large (e.g. three-generation) pedigrees. In this study, we developed a method, FamANC, that can improve the accuracy of local ancestry inference in large pedigrees by: (1) using an existing algorithm to infer local ancestries for all individuals in a family, assuming (contrary to fact) they are unrelated, and (2) improving its accuracy by correcting inference errors using pedigree structure. Applied on African-American pedigrees from the Cleveland Family Study, FamANC was able to correct all identified Mendelian errors and most of double crossovers.
Read the full article at: https://www.nature.com/articles/s41598-019-57039-w
